Molecular And Cellular Mechanisms Of Toxicity And Cancer

University of Birmingham Molecular and Cellular Mechanisms of Toxicity and Cancer Ana Luisa Perini Leme Giordano Mechanisms of neurotoxicity of Aluminum Birmingham 6 November 2014. The chemical compounds of Aluminum usually appear in the trivalent state of the molecule (Al3+) (House et al. 2010). The human exposition to Aluminum occurs mainly through alimentation, inhalation; it can also occur through drinking water, cosmetics and medicaments. (Greger et al.,1992). The occupational exposures to this metal occurs in mining and processing, also in the fabrication of Al products. (JL, Lin et al., 1997). A big number of epidemiologic studies relates the content of Aluminum in the drinking water with the increasing of the†¦show more content†¦The reason for the high concentration of Aluminum in the patient’s body can be the ingestion of aluminum hydroxide that is found in the medicine of the dialysis treatment. (Alfrey, 1796). Also, Aluminum is difficult to be dialyzable in the blood, because it is strongly bounded with proteins, and this makes it difficult to the membrane of the dialysis machine to remove the Aluminum of the patient’s body (D rueke T. 1980). The Aluminum also interferes in the Na+/K+ATPase, a protein that appears in high quantity in the neurons and in the glial cells. The main function of this protein in the brain is related with the fluidity of the membranes and the regulation of the excitability of the neurons and the maintainence of eletrochemicals gradient. (Roesky et al., 2002). The Aluminum inhibits the activity of the Na+K+ATPase, which is a target of the oxidative stress of the neuron, and this oxidative stress is a consequence of Alzheimer’s. (Roesky, 2002). The Aluminum is related to Alzheimer. Elevated levels of Aluminum in the brain can be a consequence of the Alzheimer disease. When you have the Alzheimer disease, the hematoencephalic barrier’s efficacy is reduced, and Aluminum gets in the brain easily (McLachlan). High level of Aluminum in the brain causes the formation of neurofibrilar tangles (the main characteristics of the